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NFL Week 6 Predictions and Odds: Will the Eagles put up a fight against the reigning champs?

We’re picking every game from this week’s NFL slate.

NFL: Philadelphia Eagles at Carolina Panthers Douglas DeFelice-USA TODAY Sports

The NFL’s sixth week of games kick off tonight with a matchup between the Bucs and Eagles. Tom Brady, as super-charged as ever, will get another chance to beat in the face of the franchise that kept him from one of his potential Super Bowl rings.

Like we began last week, I picked the rest of the games on the docket and included my quick thoughts on each matchup.

Curious to see who I like this weekend? Well, let’s get to it. Of course, all odds below are via DraftKings Sportsbook.

Odds/lines subject to change. T&Cs apply. See draftkings.com/sportsbook for details.

Thursday Night Football

Buccaneers (-7) vs. Eagles - O/U 52.5

Prediction: Buccaneers - Tom Brady is coming off an extremely casual game with over 400 yards passing and five touchdowns. At 44 years old, it’s never looked more natural. However, the Eagles have the ninth-ranked unit in total defense and allow the third-fewest passing yards per game with 194.8. It may look a bit lopsided on paper, but the Eagles have a chance to be a pesky opponent on Thursday Night Football.

Sunday Morning Games

Dolphins (-3) vs. Jaguars - O/U 47.5

Prediction: Jaguars - For whatever reason, I have a gut feeling that the Jaguars losing streak will finally come to an end and Trevor Lawrence will finally get that elusive first victory in the NFL. Tua Tagovailoa could make his return this week but even if that comes to pass, the Dolphins are in dire need of play-makers following some bad injury luck.

Vikings (-1.5) vs. Panthers - O/U 46

Prediction: Vikings - After a hot start to the season, the Panthers defense has cooled off tremendously and Sam Darnold is looked more like the Jets version as opposed to the new-and-improved quarterback we saw through the first three weeks. The Vikings have started slow in recent years but the defense under Mike Zimmer is really finding it’s stride as of late. If Dalvin Cook also makes his return, I like the Vikings getting to .500 on the year.

Packers (-4.5) vs. Bears - O/U 44.5

Prediction: Packers - Justin Fields will get another chance to impress as the team’s starter but he’d have to have quite the game to top Aaron Rodgers and the Packers. While the Bears defense is always a tough challenge, their offense is nowhere near the level needed to complement their play, I like the Packers to win this one handedly.

Bengals (-3.5) vs. Lions - O/U 48

Prediction: Bengals - The Lions lost last week’s game against the Vikings in heart-breaking fashion after a furious comeback in the waning minutes. They’ve been competitive just about every week but I just can’t see them being able to out-pace the Bengals and their dynamic duo of Joe Burrow and rookie wideout Ja’Marr Chase. The Lions need to find a difference-maker at wideout to really take their offense up a notch.

Texans vs. Colts (-9) - O/U 43

Prediction: Colts - Carson Wentz showed some real spunk through the first three quarters against the Ravens this past Monday night. However, the magic fizzled too soon and the Colts couldn’t close out a game in which they held a 16-point lead in the fourth. After a deflating outcome like that, there’s likely no better game to bounce back with than one against the lowly Texans. I expect Wentz to continue his notable play for one more week.

Rams (-9.5) vs. Giants - O/U 48.5

Prediction: Rams - Don’t let the lopsided loss to the Cardinals two weeks ago fool you. This is still a very good Rams squad with plenty of talent on either side of the ball. The Giants, on the other hand, just watched quarterback Daniel Jones, running back Saquon Barkley, and wide receiver Kenny Golladay all retained injuries from their game against the Cowboys. This may be a long day for New York.

Chiefs (-6.5) vs. WFT - O/U 55.5

Prediction: Chiefs - I’m sure more than anyone, Patrick Mahomes is sick and tired of all the talk surrounding the Chiefs’ 2-3 record this year. Don’t expect him and the rest of his playmakers to just sit around and do nothing about it. Kansas City will use this game against Washington as a reminder that they’re still a top team in the AFC.

Sunday Afternoon Games

Cardinals vs. Browns (-3) - O/U 49.5

Prediction: Browns - The Cardinals are legit. That’s for certain. But after what the Browns just went through, I can’t help but feel like this is a game they’ll be hellbent on winning to erase the taste of their loss to the Chargers. I believe this one will be close, but I expect the Browns to flip the script by letting their run game close this one out in the fourth.

Raiders vs. Broncos (-3.5) - O/U 44

Prediction: Broncos - After what the Raiders just went through over the past week, I just can’t see them having their minds in the right place to win a divisional game against an opponent with the NFL’s third-ranked defense. It’ll be a competitive game, as they always are in the AFC West, but the Broncos aren’t the club under an immense microscope at the moment.

Cowboys (-3.5) vs. Patriots - O/U 51

Prediction: Cowboys - Mac Jones has been playing well through his first five games. Like, surprisingly well. However, the Patriots’ style of offense isn’t geared to compete in likely shootout with the Cowboys. Unless Bill Belichick can pull some magic out of his sleeve-less hoodie, I think Dallas wins this one.

Sunday Night Football

Seahawks vs. Steelers (-5) - O/U 42.5

Prediction: Seahawks - The Seahawks have too much talent to continue this downward trend. The Steelers have the 19th-ranked pass defense which means this is an opportune game for someone like Tyler Lockett to get his groove back. After beginning the season with 278 yards through weeks one and two, Lockett has failed to break 60 yards receiving in either of the past three weeks. This one just feels right.

Monday Night Football

Bills (-5.5) vs. Titans - O/U 52

Prediction: Bills - The Bills are on a tear since losing in week one to the Steelers and I just can’t imagine that ending this week. The Titans pass defense is in the bottom half of the league and I think that’s all we need to know about how this will go.