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Road Game
The San Diego Chargers are 3-9, and that sounds terrible, but they're even worse on the road. They're 1-4 away from Qualcomm Stadium, which is hilarious when you consider how much time and energy the players and coaches have put into complaining about the home crowd, with their only win coming against the hapless Jacksonville Jaguars.
If the Chargers were going to beat the Chiefs, they would've done it when they played in San Diego. Speaking of....
Health
When the Chargers lost 33-3 to the Kansas City Chiefs, it was as healthy as Mike McCoy's team had been since the start of the regular season. That wasn't by chance, either, it was because the team was coming off a bye week in which McCoy gave his team extra rest and minimal practices to try and get that health that had been out of the team's grasp all season.
Right now, the Chargers are significantly less healthy than they were a few weeks ago. By my count, they'll be missing somewhere between 4-6 starters (out of 22 position players) when they get on the place to Missouri.
Spencer Ware
The Chargers will not be able to score very much on the Kansas City Chiefs, if their last meeting (and San Diego's performance against a similar Denver Broncos defense last week) is any indication. So they'll look to make this a low-scoring affair.
Unfortunately for them, Spencer Ware is a player.
After showing up for the first time against the Chargers, getting 11 carries for 96 rushing yards and 2 rushing touchdowns (all career highs), Ware arguable improved on that performance the next week, carrying it 19 times for 114 yards and another rushing touchdown.
The only chance the Chargers have are to take away everything but the deep ball, and then get a pass rush on Alex Smith. Unfortunately for them, the Chiefs have enough talent in the ground game that Smith probably won't be forced into that situation.