The San Diego Chargers will lose to the San Francisco 49ers

Colin Kaepernick

If I were to try and create the perfect QB to destroy the San Diego Chargers defense, I believe I'd end up building San Francisco QB Colin Kaepernick.

He's tall, mobile, has a strong arm, has great pocket presence, and can make accurate throws from outside of the pocket. Where he runs into issues is making throws from inside the pocket. That's where his accuracy seems to take a dive.

Time and again, we've seen this play out. These types of QBs will simply wait for somebody to get open downfield against the Chargers anemic pass-rush, or they'll run away from it and make a perfect pass outside of the pocket. Think Terrelle Pryor last season or even Carson Palmer in Week 1.

Kaepernick is looking to prove himself after a disappointing season and the Chargers are just the right defense for him to do that.

Philip Rivers

I have nothing against Philip Rivers, but he has looked bad for about the last month. Inaccurate and indecisive. We found out this week that Rivers has a bad injury, to go along with his chest/ribs injury, and that's been leading to the problem.

Rivers missed a day of practice, but everyone says he's ready to play on Saturday night. However, there's no reason to believe he'll be any more healthy of effective against the 49ers than he has been against the Patriots and Broncos.

Ryan Mathews

One reason Rivers has been struggling so much is that the Chargers rushing attack basically doesn't exist without Ryan Mathews. After leaving the game against the Patriots with an injury, Mathews is yet to play in a game or practice yet. While it's certainly possible that he will play against the 49ers, even that doesn't mean he'll be able to play the full game.

The Chargers are playing against one of the better defenses in the league, out to prove that they're better than their record, and the San Diego running game will be dead in their sights. Branden Oliver and Donald Brown could be in for a long night in Santa Clara.